详情介绍
Description
Biochem/physiol Actions An antineoplastic antibiotic that inhibits cell proliferation by forming a stable complex with DNA and blocking the movement of RNA polymerase which interferes with DNA-dependent RNA synthesis. Induces apoptosis. Potent antitumor agent. For cell culture applications, actinomycin D is used as a selection agent and is used in banding techniques to differentiate between different regions of chromosomes.
Caution Hygroscopic and light sensitive.
Properties
biological source from Streptomyces sp.
assay ~98% (HPLC)
form powder
color red, powder
red to orange
mp 251-253
solubility DMSO: 1 mg/mL
ethanol: soluble
storage temp. 2-8°C
Safety
Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Hazard Codes T+
Risk Statements 28
Safety Statements 22-28-36/37-45
RIDADR UN3462 6.1/PG 2
WGK Germany 3
RTECS AU1575000