Description
Biochem/physiol Actions Spectrum of Activity: Gram positive cocci and taxoplasma. Especially active against anaerobic bacteria.
Mode of Action: Inhibits protein synthesis in bacteria by binding the 50s ribosomal subunit.
Clindamycin is a semi-synthetic, lincosamide antibiotic that is prepared from lincomycin. It inhibits bacterial protein synthesis by hydrogen bond interactions with the 23S rRNA component of the 50S ribosomal subunit thus inducing dissociation of the peptidyl-t-RNA complex.
Other Notes Antibacterial and antiprotozoal antibiotic of the licosamide class.
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Properties
assay ≥98.0% （TLC）
solubility H2O: 50 mg/mL, clear, colorless
storage temp. 2-8°C

Safety
Personal Protective Equipment Eyeshields, Gloves, type N95 （US）, type P1 （EN143） respirator filter
Safety Statements 22-24/25
WGK Germany 2
RTECS GF2275000

References
Cited Reference 1. L.W. Brown et al. Anal. Profiles Drug Subst. 10, 75, （1981）
reference Spizek, J., and Rezanka, T., Lincomycin, clindamycin and their applications. Appl. Microbiol. Biotechnol. 64, 455-464, （2004）
  Tenson, T., et al., The mechanism of action of macrolides, lincosamides and streptogramin B reveals the nascent peptide exit path in the ribosome. J. Mol. Biol. 330, 1005-1014, （2003）
  Kouvela, E.C., et al., Unraveling new features of clindamycin interaction with functional ribosomes and dependence of the drug potency on polyamines. J. Biol. Chem. 281, 23103-23110, （2006）
  Cullmann,W., et al., Antibacterial activity of oral antibiotics against anaerobic bacteria. Chemotherapy 39, 169-174, （1993）
  Leigh, D.A., Antibacterial activity and pharmacokinetics of clindamycin. J. Antimicrob. Chemother. 7 Suppl. A, 3-9, （1981）

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