Description
Biochem/physiol Actions Antibiotic that concentrates in kidney and bladder; reduces nephrotoxicity and ototoxicity of platinum-containing anti-tumor agents. Fosfomycin inhibits UDP-GlcNAc enolpyruvyl tranferase （MurA）, an enzyme involved in bacterial cell wall biosynthesis.
Legal Information VETRANAL is a registered trademark of Sigma-Aldrich Biotechnology LP and Sigma-Aldrich Co.

Properties
grade VETRANAL®, analytical standard

Safety
Personal Protective Equipment Eyeshields, Gloves, type N95 （US）, type P1 （EN143） respirator filter
WGK Germany 3

References
reference Kim, D.H., et al., Characterization of a Cys115 to Asp substitution in the Escherichia coli cell wall biosynthetic enzyme UDP-GlcNAc enolpyruvyl transferase （MurA） that confers resistance to inactivation by the antibiotic fosfomycin. Biochemistry 35, 4923-4928, （1996）

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