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腺苷/腺嘌呤核苷/9-β-D-呋喃核糖基腺嘌呤/腺素苷/胰苷/腺呤配糖/腺尿环核苷/Adenosin
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型号:Z0045

更新时间:2017-07-07  |  阅读:1215

详情介绍

 Description
Biochem/physiol Actions Endogenous neurotransmitter at adenosine receptors. Cardioprotective effects may relate to activation of A1 adenosine receptors. The antiplaet and anti−inflammatory actions of adenosine appear to be mediated via the A2 adenosine receptor. In contrast, adenosine appears to be a pro-inflammatory mediator in asthma and chronic obstructive pulmonary disease (COPD).

Properties
assay ≥99%
mp 234-236 °C(lit.)
Gene Information human ... ADA(100), ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140), ERBB2(2064), ERBB4(2066)
  rat ... Adcy2(81636), Adora1(29290), Adora2a(25369), Adora3(25370)
storage temp. 2-8°C

Safety
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
WGK Germany 2
RTECS AU7175000

References
reference Hutchinson, S.A., and Scammells, P.J., A1 adenosine receptor agonists: medicinal chemistry and therapeutic potential. Curr. Pharm. Des. 10, 2021-2039, (2004)
  Fredholm, B.B., et al., Actions of Adenosine at Its Receptors in the CNS: Insights from Knockouts and Drugs. Annu. Rev. Pharmacol. 27, (2004)
  Livingston, M., et al., Adenosine, inflammation and asthma--a review. Inflamm. Res. 53, 171-178, (2004)
  Sullivan, G.W., Adenosine A2A receptor agonists as anti-inflammatory agents. Curr. Opin. Investig. Drugs 4, 1313-1319, (2003)
  Rorke, S., and Holgate, S.T., Targeting adenosine receptors: novel therapeutic targets in asthma and chronic obstructive pulmonary disease. Am. J. Respir. Med. 1, 99-105, (2002)
Merck Merck 13,154
Beilstein Beil. 26,IV,3598
  FT-IR 1 (2), 720:A / FT-IR 2 (3), 3684:C / FT-NMR 1 (3), 222:A / IR-Spectra (3), 1296:E / IR-Spectra (2), 1128:F / NMR-Reference 2 (2), 597:C / RegBook 1 (2), 2475:K / Sax 6, 138 / Sigma FT-IR 1 (1), 752:C / Structure Index 1, 391:A:6

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