详情介绍
Description
Biochem/physiol Actions Naturally-occurring activator of cyclic-AMP-dependent protein kinase (PKA). cAMP is an important second messenger that is linked in many systems to neurotransmitter- or hormone-induced receptor stimulation. The cAMP/PKA signaling pathway has been shown to inhibit cell proliferation, induce differentiation and lead to apoptosis.
Properties
assay ≥99% (HPLC)
form powder
color white
mp 260 °C (dec.)(lit.)
solubility H2O: 10 mg/mL, clear, colorless (pH of aqueous solution is approx. 3.0. The sodium salt (A6885) is about 20× more soluble.)
Gene Information human ... OPRK1(4986)
storage temp. −20°C
Safety
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Safety Statements 22-24/25
WGK Germany 3
RTECS AU7357600
References
reference Daniel, P.B., et al., Cyclic AMP signaling and gene regulation. Annu. Rev. Nutr. 18, 353-383, (1998)
Spada, A., et al., Cyclic AMP and calcium in the transduction of hypothalamic neurohormone action in human pituitary tumors. Horm. Res. 47, 235-239, (1997)
Chen, T.C., et al., Up-regulation of the cAMP/PKA pathway inhibits proliferation, induces differentiation, and leads to apoptosis in malignant gliomas. Lab. Invest. 78, 165-174, (1998)
Merck Merck 13,2737
Beilstein Beil. 26,IV,3618
FT-IR 1 (2), 725:A / FT-IR 2 (3), 3691:C / FT-NMR 1 (3), 229:A / IR-Spectra (2), 1133:G / IR-Spectra (3), 1301:F / NMR-Reference 2 (2), 605:D / RegBook 1 (2), 2481:D / Sigma FT-IR 1 (1), 805:C / Structure Index 1, 392:D:3
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