详情介绍
Description
Biochem/physiol Actions An important second messenger, cGMP is a major intracellular mediator of extracellular signals such as nitric oxide and natriuretic peptides. Cyclic GMP interacts with three types of intracellular receptor proteins: cGMP-dependent protein kinases, cGMP-regulated channels, and cGMP-regulated cyclic nucleotide phosphodiesterases. A primary action of elevated cGMP levels in vivo is the stimulation of cGMP-dependent protein kinase (PKG).
Properties
assay ≥99% (HPLC)
form powder
color white
solubility H2O: 50 mg/mL
storage temp. −20°C
Safety
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
WGK Germany 3
References
reference Vaandrager, A.B., and de Jonge, H.R., Signalling by cGMP-dependent protein kinases. Mol. Cell Biochem. 157, 23-30, (1996)
Lohmann, S.M., et al., Distinct and specific functions of cGMP-dependent protein kinases. Trends Biochem. Sci. 22, 307-312, (1997)
Wang, X., and Robinson, P.J., Cyclic GMP-dependent protein kinase and cellular signaling in the nervous system. J. Neurochem. 68, 443-456, (1997)
Browning, D.D., et al., Activation of p38 mitogen-activated protein kinase by lipopolysaccharide in human neutrophils requires nitric oxide-dependent cGMP accumulation. J. Biol. Chem. 274, 537-542, (1999)
Bevans, C.G., and Harris, A.L., Direct high affinity modulation of connexin channel activity by cyclic nucleotides. J. Biol. Chem. 274, 3720-3725, (1999)
Finn, J.T., et al., Cyclic nucleotide-gated ion channels: an extended family with diverse functions. Annu. Rev. Pharmacol. Toxicol. 58, 395-426, (1996)
Zagotta, W.N., and Siegelbaum, S.A., Structure and function of cyclic nucleotide-gated channels. Annu. Rev. Neurosci. 19, 235-263, (1996)
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