Description
Biochem/physiol Actions Ara-C incorporates into DNA and inhibits DNA replication by forming cleavage complexes with topoisomerase I resulting in DNA fragmentation; does not inhibit RNA synthesis. Anti-leukemia agent.

Properties
assay ≥99.0% （HPLC）
optical activity [α]20/D +158±2°, c = 1% in H2O
solubility H2O: 50 mg/mL, clear, colorless
Gene Information human ... POLB（5423）
  mouse ... Cda（72269）

Safety
Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 （US）, Gloves, respirator cartridge type N100 （US）, type P1 （EN143） respirator filter, type P3 （EN 143） respirator cartridges
Hazard Codes Xn
Risk Statements 43-63
Safety Statements 36/37
WGK Germany 3
RTECS HA5425000

References
Merck Merck 13,2813
Beilstein Beil. 25,IV,3669

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