Description
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Application Mild nonionic detergent used to solubilize receptors and permeabilize cellular and nuclear membranes.
Quality Preparation is free of water-insoluble constituents.

Properties
optical activity [α]20/D −54°, c = 2.8 in methanol（lit.）
mol wt micellar avg mol wt 70,000
aggregation number 60
color white
CMC <0.5 mM（20-25°C）
mp 230-240 °C （dec.）（lit.）
solubility H2O: 5 % （w/v） （solubilized by heating to 95 °C - 98 °C and then cooling to room temp.）

Safety
Personal Protective Equipment Eyeshields, Faceshields, Gloves, type P2 （EN 143） respirator cartridges
Hazard Codes T
Risk Statements 23/24/25
Safety Statements 22-28-36/37-45
RIDADR UN3462 6.1/PG 3
WGK Germany 3
RTECS IH2050050

References
reference Karl, J., et al., GFAP phosphorylation studied in digitonin-permeabilized astrocytes: standardization of conditions. Brain Res. 853, 32-40, （2000） Abstract
  Liu, J., et al., Use of digitonin-permeabilized cells in studies of steroid receptor subnuclear trafficking. Methods 19, 403, （1999） Abstract
  Prehm, S., et al., A mild purification method for polysaccharide binding membrane proteins: phase separation of digitonin extracts to isolate the hyaluronate synthase from Streptococcus sp. in active form. Protein Expr. Purif. 7, 343-346, （1996） Abstract
  Nock, B., Extracti-Gel D chromatography is a simple efficient method for removing digitonin during receptor purification: application to the κ1 opioid receptor. J. Neurosci. Methods 50, 353, （1993） Abstract
Merck Merck 13,3183
Beilstein Beil. 19,V,3,603
  Aldrich MSDS 1, 695:B / Corp MSDS 1 （1）, 1253:C / RegBook 1 （2）, 2857:E / Sax 6, 1035 / Sigma FT-IR 1 （1）, 584:D

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